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Adults With Growth Hormone Deficiency (GHD) Growth hormone (GH) treatment of adults with GHD should be considered and has been associated with improved body composition, reduced body fat, and increased lean body mass. Patients with documented idiopathic GHD in childhood should be restudied in adulthood. For the average 70-kg man, the recommended dosage at the start of therapy is not more than 0.3 mg, given as a daily subcutaneous injection. Maximal doses are variable, with younger patients (<25 years) sometimes requiring up to 2 mg/day and older patients much less (sometimes only 0.1 or 0.2 mg/day). The clinician must exercise good clinical judgment by assessing side effects, serum insulin-like growth factor I (IGF-I) levels, and changes in body composition to determine the appropriate maintenance dose. In older or overweight patients, lower doses may be needed to minimize the occurrence of adverse events. During therapy, the dosage should be decreased if side effects occur or IGF-I levels are excessive. The maintenance dose depends on the clinical and biochemical response. These doses should be altered to maintain circulating levels of IGF-I in the normal range for the patientīs age and sex. Serum free thyroxine and lipid levels should be assessed initially and at 6 to 12 months thereafter. Plasma glucose concentration is analyzed initially and every 3 months. Long-term treatment is being evaluated at this time. |